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Soon after arriving in Seattle, Derek met Meredith Grey at a bar and went home with her for a one-night stand, only to discover the next day that she was a new surgical intern at the hospital. Although she initially rejected his advances as inappropriate due to their working relationship, Meredith eventually agreed to date Derek, although he did not tell her about his marriage. His charismatic, charming personality and good looks earned him the nickname “McDreamy” among Meredith and her friends. However, their fledgling relationship came to a sudden halt when Addison arrived in Seattle for a consult upon Richard Webber’s request. Addison had also brought divorce papers, but made it clear that if Derek was willing to give her a second chance, she wanted to give their marriage another try. Derek struggled over his choice, but ultimately his sense of obligation to his marriage vows won, and he left Meredith to return to his wife. The choice was not as simple as Derek had anticipated, and he found that he still had very strong feelings for Meredith, even as he tried to repair his marriage to Addison. Shortly before Christmas, he confessed to Addison that Meredith had not just been a fling, but that he’d fallen in love with her; Addison was willing to wait it out, although the situation was complicated further when she and Derek took in Meredith’s dog, Doc. Although Derek eventually admitted that the problems in their marriage were partially his fault, his love for Meredith continued to make him emotionally distant from Addison. When Meredith began dating Finn Dandridge, Doc’s veterinarian, Derek became so withdrawn and consumed with jealousy that Addison confronted Derek about his ongoing infatuation with Meredith, and even asked Meredith if she was sleeping with Derek. At a hospital-sponsored prom for the chief's dying niece, Derek and Meredith’s emotional affair reached the point of no-return. After a heated argument in an exam room, Derek and Meredith had sex, but before they could discuss the implications of their actions, Meredith was called away to deal with Izzie, whose fiancé had just died. The next day, Addison found Meredith’s panties, which had been left in Derek’s tuxedo jacket, and pinned them to the hospital bulletin board, while Derek went to Meredith’s house and professed his love to her for the first time. Their reunion, however, was not immediate. Initially, Derek felt immense guilt over the breakdown of his marriage with Addison, and went to the hotel room where she was staying to apologize. Instead, he was appalled to find out that Addison, in a drunken stupor, had called Mark in New York to fly to Seattle for a "trans-continental booty call". To Derek's disdain, Mark decided to take up a position at Seattle Grace in a bid to woo Addison back. Although he and Addison acknowledged the end of their marriage and began divorce proceedings, Meredith was less certain, and decided to date both Derek and Finn before making a decision between the two. While they were dating, Meredith was admitted for an appendectomy, and Finn’s concern for her during her illness led Derek to reconsider his pursuit of her. As she recovered from surgery, he told Meredith that he was walking away, freeing her to be with Finn, whom he considered “the better guy”. Meredith, however, had already decided that Derek was “the one” for her, and broke up with Finn. She kept the break-up from Derek for another week, and made the unfortunate timing mistake of telling him just after Addison had confessed that she and Mark had not just been a one-night stand, as she had led Derek to believe, but had actually lived together for two months after Derek left for Seattle. Meredith’s introduction to Derek’s family was no less problematic; she stopped by the trailer one night to talk to Derek and discovered a strange woman lying across Derek’s bed and Derek, wearing nothing more than a towel and a very startled expression. She would later learn that the woman was Derek’s sister, Nancy, but the explanation of the misunderstanding did not make Meredith any more appealing to Nancy, who continually referred to Meredith as the “slutty intern”. Derek defended Meredith, leading Nancy to acknowledge Derek’s feelings for her, but Nancy encouraged her brother to take some time to figure out what he wanted rather than worrying about the women in his life. Following Nancy’s advice, Derek asked Meredith for time to take some space for himself, and then embarked on a very brief camping trip, which only cemented his desire for Meredith. He found her in the very place they had first met—Joe’s bar—and they agreed to start their relationship over from the very beginning. Derek's professional life hit an obstacle when Richard Webber announced his plans to retire. Derek had originally been promised the chief position when Richard offered him the job in Seattle, but was surprised to find that the position had instead been offered to Preston Burke. When word got out about Richard's retirement, Addison and Mark joined in the race for chief. After a disastrous accident involving a ferry boat, Derek was sent to the scene to assess and treat head traumas. When he found her ID tag on a patient, Derek realized that Meredith was missing, and noticed that the young girl who had been with Meredith was unattended. The young girl led Derek to the edge of the dock and communicated that Meredith had fallen into the water. Derek jumped in after her and pulled her out, but despite continuous CPR, she was still unresponsive upon arriving at the hospital. Derek worked to revive her until his colleagues took over and sent him to wait in the hall while they tried to save Meredith's life. While he waited, he confronted Ellis Grey over her responsibility for Meredith’s mental state, and tried unsuccessfully to revive her when she flatlined soon after. When Meredith recovered and woke up, he broke the news to her of her mother's death and spent the night with her in her hospital bed. As Meredith recovered from her ordeal and returned to work, Derek became very protective of her, partly due to his own guilt over his inability to prevent the accident or save her life. His concern over Meredith provided a distraction during his interview for the chief position, and he admitted to Meredith that he didn't think it went very well. When Derek discussed his candidacy with the Chief, Webber expressed concern over the effect the demands of the job would have on Derek's relationship with Meredith. Derek insisted that he could balance his personal and professional lives, but was forced to face the issue Meredith presented in his career progression. After avoiding her for several days, Derek finally expressed some of his anxieties and told Meredith that he wasn't sure he could continue in their relationship if he had to "breathe for" her. Meredith assured him that she wanted to make their relationship work and would try to be better about letting him in, but after several personal crises, she continued to withdraw, despite Derek's offers and attempts to support her. As the distance between them grew, Derek was tempted to accept a drink from a woman he met at Joe's during Burke's bachelor party, but ultimately refused. The next day, he admitted meeting the woman (who unbeknown to both, was Meredith's half-sister Lexie) to Meredith and confronted her over her level of commitment to their relationship. He told her she was the love of his life, but asked that she end the relationship if she was not equally committed. Meredith did not address the issue, and instead focused on helping Cristina through her failed wedding, leaving her relationship with Derek uncertain. The same day, Webber offered the Chief position to Derek, but he declined to accept it and instead encouraged Richard to stay on as Chief. wikipedia.org